Generic Name: oxandrolone 2.5MG
Unlike most oral steroids, which are Class II steroids giving most of their anabolic effect by means other than the androgen receptor (AR), it seems that oxandrolone probably does have good binding to the AR, and is therefore a Class I steroid, while having little other effect. By itself it is considered to be a weak anabolic.
Partly this is due to its apparent lack of non-AR-mediated activity. This can be corrected of course by stacking with a Class II steroid such as dianabol, anadrol, 4-AD, or nor-4-AD: the latter two steroids require high blood levels which are not obtained by oral use of the powders.
The other part of the reason for this is that bodybuilders make unfortunate and unreasonable comparisons when judging anabolic steroids. If say 8 tablets per day does little, then the drug is pronounced useless or weak by the user. But that is only 20 mg/day, or 140 mg/week. Does 140 mg/week testosterone give much results? No. Few anabolic steroids give dramatic results at that dose. Per milligram the potency is reasonable, but each individual tablet is weak because the dosage is small.
Because of its high price, very few bodybuilders have taken large doses of oxandrolone. There is a single case in the medical literature (Forbes et al.) where it is reported that a competitive athlete self-administered 150 mg oxandrolone per day with remarkable gains. This is of uncertain credibility because unless urinalysis was done to verify that no other steroids were taken, there is no way to be certain that the athlete did not actually take more drugs than he reported. In any case, at current prices, only the quite wealthy could afford such a dose. I personally have tried 150 mg/day and considered it somewhat effective, but not dramatically so, and not a preferred regimen.
Oxandrolone does not aromatize or convert to DHT, and has a longer half life than Dianabol - 8 hours vs. 4 hours. Thus, a moderate dose taken in the morning is largely out of the system by night, yet supplies reasonable levels of androgen during the day and early evening.
Oxandrolone shares the liver toxicity problems common to 17-alkylated steroids. At one time it was thought that it did not, but both clinical and practical experience with Oxandrin has shown that at doses of 40 mg/day and higher, liver toxicity is indeed an issue with prolonged use.
Primobolan, I believe, should be considered a superior compound, offering the same activity at (usually) a lower price and without the alkylated-toxicity issue.
Effective Dose: 1 - 3 tabs per day
Anavar / Oxandrolone / Oxandrin
Description:
by Bill Roberts - Unlike most oral steroids, which are Class II steroids giving most of their anabolic effect by means other than the androgen receptor (AR), it seems that oxandrolone probably does have good binding to the AR, and is therefore a Class I steroid, while having little other effect. By itself it is considered to be a weak anabolic.
Partly this is due to its apparent lack of non-AR-mediated activity. This can be corrected of course by stacking with a Class II steroid such as Dianabol , Anadrol® , 4-AD, or nor-4-AD: the latter two steroids require high blood levels which are not obtained by oral use of the powders.
The other part of the reason for this is that bodybuilders make unfortunate and unreasonable comparisons when judging anabolic steroids. If say 8 tablets per day does little, then the drug is pronounced useless or weak by the user. But that is only 20 mg/day, or 140 mg/week. Does 140 mg/week testosterone give much results? No. Few anabolic steroids give dramatic results at that dose. Per milligram the potency is reasonable, but each individual tablet is weak because the dosage is small.
Because of its high price, very few bodybuilders have taken large doses of oxandrolone. There is a single case in the medical literature (Forbes et al.) where it is reported that a competitive athlete self-administered 150 mg oxandrolone per day with remarkable gains. This is of uncertain credibility because unless urinalysis was done to verify that no other steroids were taken, there is no way to be certain that the athlete did not actually take more drugs than he reported. In any case, at current prices, only the quite wealthy could afford such a dose. I personally have tried 150 mg/day and considered it somewhat effective, but not dramatically so, and not a preferred regimen.
Oxandrolone does not aromatize or convert to DHT, and has a longer half life than Dianabol - 8 hours vs. 4 hours. Thus, a moderate dose taken in the morning is largely out of the system by night, yet supplies reasonable levels of androgen during the day and early evening.
Oxandrolone shares the liver toxicity problems common to 17-alkylated steroids. At one time it was thought that it did not, but both clinical and practical experience with Oxandrin has shown that at doses of 40 mg/day and higher, liver toxicity is indeed an issue with prolonged use.
Primobolan , I believe, should be considered a superior compound, offering the same activity at (usually) a lower price and without the alkylated-toxicity issue.
Anavar (Oxandrolone)
Anavar, oxandrolone, tablets. Each Anavar tablet contains 2.5 mg. oxandrolone. Anavar, brand name Bonavar, comes in packs of 50 tablets and is manufactured by Body Research Ltd., Thailand.
Common uses and directions for Anavar, oxandrolone
Oxandrolone has often been used as a growth-promoting agent in the therapy of boys with growth delays in adolescence. Oxandrolone is also used in treating girls affected with Turner's syndrome, another growth-delay ailment. In obese individuals, oral oxandrolone has been shown to decrease subcutaneous abdominal fat more than Testosterone enanthate or weight loss alone, and it also tended to produce favorable changes in visceral fat.
Athletes like oxandrolone for three reasons. First, oxandrolone causes a strong strength gain by stimulating the phosphocreatine synthesis in the muscle cell without depositing water in the joints and the muscles.
Secondly, oxandrolone is one of the very few steroids that does not aromatize into estrogen, at any dosage, which has various advantages for the athlete.
The third reason for the popularity of Anavar is that oxandrolone does not influence the body's own testosterone production.
A suitable dosage of Anavar for a male athlete is 0.125 mg./pound of body weight per day. Women should not take more than about half of that dosage, though. Anavar is normally taken two to three times daily after meals thus assuring an optimal absorption of the oxandrolone.
Oxandrolone can give gastrointestinal problems ranging from a sensation of stomach fullness to appetite suppression, nausea, and diarrhea.
More information about Anavar (Oxandrolone):
Anavar (Oxandrolone) additional information
Common uses
Oxandrolone is one of the few steroids, which does not cause an early stunting of growth in children since it does not prematurely close the epiphysial growth plates. For this reason oxandrolone is mostly used in children to stimulate growth and in women to prevent osteoporosis. In obese individuals, oral oxandrolone has been shown to decrease subcutaneous abdominal fat more than testosterone enanthate or weight loss alone, and it also tended to produce favorable changes in visceral fat.
Athletes like oxandrolone for three reasons. First, oxandrolone causes a strong strength gain by stimulating the phosphocreatine synthesis in the muscle cell without depositing water in the joints and the muscles.
Secondly, oxandrolone is one of the very few steroids that does not aromatize into estrogen, at any dosage, which has various advantages for the athlete.
The third reason for the popularity of Anavar is that oxandrolone does not influence the body's own testosterone production. This special feature of Anavar can be explained by the fact that the oxandrolone is not converted into estrogen.
Oxandrolone causes very light virilization symptoms, if at all. This characteristic makes Anavar a favored remedy for female athletes since, at a daily dose of 10-15 mg., masculinizing symptoms are observed only rarely.
Directions
Anavar, brand name Bonavar, as a tablet, containing 2.5 mg. oxandrolone, to take by mouth.
Anavar should be taken two to three times daily after meals thus assuring an optimal absorption of the oxandrolone. Common dosage is 8-12 tablets in men and 5-6 tablets in women. The rule of thumb to take 0.125 mg./pound of body weight daily has proven successful in clinical tests.
Anavar can be combined with almost any other steroid such as Winstrol , Deca durabolin, Dianabol , or Anadrol .
If you miss a dose, take it as soon as remembered if it is within an hour or so. If you do not remember until later, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.
Precautions
Women should not take more than 15 mg. daily otherwise, androgenic-caused side effects such as acne, deep voice, clitorial hypertrophy or increased growth of body hair can occur.
Since oxandrolone is only slightly toxic and usually shows few side effects, several athletes use it over a prolonged period of time. However Anavar should not be taken for several consecutive months, since, as with almost all oral steroids it is 1 7-alpha alkylated and thus liver toxic.
Possible side effects
Oxandrolone can give gastrointestinal problems ranging from a sensation of stomach fullness to appetite suppression, nausea, and diarrhea. The symptoms can be reduced by taking the tablets one-two hours after the meals.
Oxandrolone has negative effects on blood lipids.
In females, dosages above 15 mg./day can cause facial hair, deepening of the voice, clitoral hypertrophy, and acne.
If you notice other effects not listed above, contact your doctor.
Overdose
If overdose of anavar is suspected, contact your local poison control center or emergency room immediately.
Additional information
Keep oxandrolone in a tightly closed container and out of reach of children. Store oxandrolone at room temperature and away from excess heat and moisture (not in the bathroom).
Note
The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, or other healthcare professional. It should not be construed to indicate that use of oxandrolone is safe, appropriate, or effective for you. Consult your healthcare professional before using anavar.
Oxandrolone
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Oxandrolone
|
| Systematic (IUPAC) name |
| 17b-hydroxy-17a-methyl-2-oxa-5a-androstan-3-one |
| Identifiers |
| CAS number |
53-39-4 |
| ATC code |
A14AA08 |
| PubChem |
5878 |
| DrugBank |
APRD01151 |
| Chemical data |
| Formula |
C19H30O3 |
| Mol. mass |
306.44 g/mol |
| Pharmacokinetic data |
| Bioavailability |
97% |
| Metabolism |
Hepatic |
| Half life |
9 hour[1] |
| Excretion |
Urinary:90%; Fecal:6% |
| Therapeutic considerations |
| Pregnancy cat. |
X
|
| Legal status |
Prescription only (US)
|
| Routes |
Oral |
Oxandrolone (Oxandrin) is an anabolic steroid created by Searle Laboratories, now Pfizer Inc. under the trademark Anavar, and introduced into the US in 1964. It is taken orally, and unlike other steroids delivered in this manner, most of which are Class II steroids, the majority of its effects are due to reaction with the androgen receptor. In sufficient dosage, Oxandrolone is highly likely to bind well with the receptor, and is therefore a Class I steroid, while having few other side-effects.
As opposed to most other anabolic steroids Oxandrolone has two major advantages: First, it does not aromatize (convert to estrogen which causes gynecomastia - breast tissue). Second, it does not significantly influence the body's normal testosterone production (HPTA axis) at low dosages (10mgs). When dosages are high (this goes for any anabolic steroid) then your body feels that it has enough testosterone and it reduces the production of LH (luteinizing hormone) which no longer stimulates Leydig cells in testicles to produce testosterone therefore causing testicular atrophy (shrinking). Post Cycle Therapy (PCT) is of course needed for high dosages (40-50mg) of this synthetic derivative of testosterone because as the dosage increases the influence on HPTA is bigger. Lack of PCT will of course lead to protein catabolism until body's normal testosterone secretion is back to normal.
The drug was prescribed for a number of medical disorders causing involuntary weight loss, in order to promote muscle regrowth. It had also been shown to be partially successful in treating cases of osteoporosis. However, in part due to bad publicity from its abuses by bodybuilders, Oxandrolone was discontinued by Searle Laboratories in 1989. It was picked up by Bio-Technology General Corporation, now Savient Pharmaceuticals, Inc. who, following successful clinical trials in 1995, released it under the tradename Oxandrin.
It was approved for orphan drug status by the Food and Drug Administration (FDA) in treating alcoholic hepatitis, Turner's syndrome, and weight loss caused by HIV. In addition, the drug has shown positive results in treating anaemia and hereditary angioedema. In a randomized, double-blind study, patients with 40% total body surface area burns were selected to receive standard burn care plus Oxandrolone, or without Oxandrolone. Those treated with Oxandrolone showed improve body composition, preserved muscle mass and reduced hospital stay time.[2] Other studies however have shown links between prolonged use of the drug and problems of liver toxicity similar to those found with other 17α-alkylated steroids. Even in small dosages, many users reported gastro-intestinal problems such as bloating, nausea, skin rash and itching (hives), black, tarry stools or light-colored stools, depression, unusual bleeding, unusual swelling, yellowing of the eyes or skin, and diarrhoea.
In rare cases, serious and even fatal cases of liver problems have developed during treatment with oxandrolone. Oxandrolone may increase the amount of low density lipoprotein (LDL; 'bad cholesterol') and decrease the amount of high density lipoprotein (HDL; 'good cholesterol') in the blood. This may increase the risk of developing heart disease. Oxandrolone may damage the liver or increase LDL without causing symptoms. It is important to have regular laboratory tests to be sure that the liver is working properly and that LDL has not increased. Oxandrolone may also decrease fertility in men.
Before the Controlled Substances Act was passed to restrict the production, sale, and usage of anabolic steroids, Oxandrolone's characteristics lent itself well towards use by female athletes. Its specificity targeting the androgen receptor meant that, unlike many other steroids, it had not been reported to cause stunted growth in younger users (because it doesn't convert to estrogen, that's the reason women typically don't grow as tall as men -- they have more estrogen) and at typical dosage rarely caused noticeable masculinising effects outside of stimulating muscle growth. It is not easily metabolised into DHT or estrogen. As such, a typical dose of 20-30 mg provided elevated androgen levels for up to eight hours. To increase effectiveness, bodybuilders typically "stacked" the drug with others such as Testosterone, further enhancing body mass gain.
Bodybuilders consider a normal dose for a novice being 20-30mg's per day when in fact 10 mg is more than enough for someone who never had used. Higher dosages not only lead to AR (Androgen Receptor) damage and HPTA suppression but also damages the liver being a 17α-alkylated. It is specially made 17α-alkylated because if it would not be then the liver would consider it a toxin and would destroy it.
Since Searle stopped production, biggest sellers are La Pharma Italy and British Dragon Thailand.